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PARP2 Antibody - middle region : HRP (ARP33758_P050-HRP)

Product Specifications

Gene Name

Poly (ADP-ribose) polymerase 2

Gene Aliases

ARTD2, ADPRT2, PARP-2, ADPRTL2, ADPRTL3, pADPRT-2

Gene ID

10038

Swiss Prot

Q9UGN5

Accession Number

NP_005475

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PARP2

Target

This gene encodes poly (ADP-ribosyl) transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly (ADP-ribosyl) ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

Partner Proteins

UHRF1; Npm1; TFAP4; UBC; RNF146; H3F3A; CBX5; TRIM28; CHD1L; TNP2; HSPA2; BUB3; CASP8; XRCC1; PARP1; CENPB; CENPA

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IF, WB

Purification

Affinity Purified

Sample Type

PARP2 is strongly supported by BioGPS gene expression data to be expressed in Raji

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 92%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 92%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

61kDa

References & Citations

Malanga, M. et al., (2004) J. Biol. Chem. 279 (7), 5244-5248

Shipping Conditions

Wet Ice

Protein Length

534

NCBI Gene Symbol

PARP2

NCBI GB Accession Number

PARP2

Host or Source

Rabbit

Protein Name

Poly [ADP-ribose] polymerase 2

Nucleotide Accession Number

NM_005484

Peptide Sequence

LLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAHPEA

Frequently Asked Questions

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