TP73 Antibody - N-terminal region : Biotin (ARP33457_P050-Biotin)

TP73 belongs to the p53 family. It participates in the apoptotic response to DNA damage. When overproduced, it activates transcription from p53-responsive promoters and induces apoptosis. TP53 may be a tumor suppressor protein. This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined.

FUS; YAP1; WWOX; UBC; TRIM32; SOX2; PFDN5; MYC; EP300; CDK2; CCNE1; CCNB1; CCNA2; CCND1; XPO1; PIN1; AURKA; PRKACA; MAD2L1; HSPA9; CDC20; TP53BP1; RBX1; DDB1; RCHY1; KAT2B; NEDD8; MDM2; IKBKB; DAXX; CHUK; BUB1B; BRCA1; TNK2; AMPH; CREBBP; KAT5; CEP131; MD

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.