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TBX3 Antibody - middle region : Biotin (ARP33411_P050-Biotin)

Product Specifications

Gene Name

T-box 3

Gene Aliases

UMS, XHL, TBX3-ISO

Gene ID

6926

Swiss Prot

O15119

Accession Number

NP_057653

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TBX3

Target

TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.

Partner Proteins

CA8; AES; SOX2; Dlg4; ELAVL1; HDAC5; HDAC3; HDAC2; HDAC1; TOLLIP; TBX3

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 92%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 100%; Rat: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

79kDa

References & Citations

Yarosh, W., (2008) Cancer Res. 68 (3), 693-699

Shipping Conditions

Wet Ice

Protein Length

743

NCBI Gene Symbol

TBX3

NCBI GB Accession Number

TBX3

Host or Source

Rabbit

Protein Name

T-box transcription factor TBX3

Nucleotide Accession Number

NM_016569

Peptide Sequence

VGTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGS

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