ACTL6A Antibody - N-terminal region : Biotin (ARP33350_P050-Biotin)

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

UBC; BMI1; HECW2; FBXO6; HDAC2; CBX5; UCHL5; ARID1B; RUVBL1; TRRAP; ARID1A; SMARCE1; SMARCC2; SMARCC1; SMARCA4; SMARCA2; UBD; GRB2; INO80E; CAND1; CUL3; CDK9; CDK2; H2AFZ; TP53; UL27; SMARCD1; HDGF; SOX2; SMARCAD1; KAT5; PBRM1; Bcl7b; INO80C; ACTR8; INO80

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.