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EPC1 Antibody - middle region : HRP (ARP33343_P050-HRP)

Product Specifications

Gene Name

Enhancer of polycomb homolog 1 (Drosophila)

Gene Aliases

Epl1

Gene ID

80314

Swiss Prot

Q9H2F5

Accession Number

NP_079485

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human EPC1

Target

EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Partner Proteins

RINT1; KRT15; Hopx; TRIM27; H2AFZ; DMAP1; ING3; MORF4L1; KAT5; MYC; MORF4L2; MRGBP; EED; EZH2; E2F6; SRF

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

93kDa

References & Citations

Kee, H.J., (2007) J. Biol. Chem. 282 (10), 7700-7709

Shipping Conditions

Wet Ice

Protein Length

836

NCBI Gene Symbol

EPC1

NCBI GB Accession Number

EPC1

Host or Source

Rabbit

Protein Name

Enhancer of polycomb homolog 1

Nucleotide Accession Number

NM_025209

Peptide Sequence

VNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAALPVFNAKDLNQY

Frequently Asked Questions

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