SP3 Antibody - middle region : Biotin (ARP33336_P050-Biotin)

Product Specifications

Gene Name

Sp3 transcription factor

Gene Aliases

SPR2

Gene ID

6670

Swiss Prot

Q02447

Accession Number

NP_003102

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SP3

Target

SP3 is a transcriptional factor that can act as an activator or repressor, probably in a isoform-specific manner. SP3 binds to GT and GC boxes promoters elements.This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.

Partner Proteins

SP1; SUMO1; PPP2R4; PPP1CC; GCH1; HLTF; TFAP4; YY1; SUMO2; UBC; RELA; MECP2; HDAC2; HDAC1; ZBTB7B; EP300; CRX; TP53; NKX3-1; CREBBP; CEBPB; ESR1; DNMT1; SFPQ; PIAS1; GRIN1; GABPA; ZBTB7A; UBE2I; STK19; RBBP4; E2F1; RB1; SP4; TNFSF10; SENP1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

SP3 is supported by BioGPS gene expression data to be expressed in U2OS

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.