SP3 Antibody - middle region: HRP (ARP33336_P050-HRP)
Product Specifications
Gene Name
Sp3 transcription factor
Gene Aliases
SPR2
Gene ID
6670
Swiss Prot
Q02447
Accession Number
NP_003102
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SP3
Target
SP3 is a transcriptional factor that can act as an activator or repressor, probably in a isoform-specific manner. SP3 binds to GT and GC boxes promoters elements.This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.
Partner Proteins
SP1; SUMO1; PPP2R4; PPP1CC; GCH1; HLTF; TFAP4; YY1; SUMO2; UBC; RELA; MECP2; HDAC2; HDAC1; ZBTB7B; EP300; CRX; TP53; NKX3-1; CREBBP; CEBPB; ESR1; DNMT1; SFPQ; PIAS1; GRIN1; GABPA; ZBTB7A; UBE2I; STK19; RBBP4; E2F1; RB1; SP4; TNFSF10; SENP1
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Sample Type
SP3 is supported by BioGPS gene expression data to be expressed in U2OS
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
82kDa
Shipping Conditions
Wet Ice
Protein Length
781
NCBI Gene Symbol
SP3
Protein Name
Transcription factor Sp3
Nucleotide Accession Number
NM_003111
Curated Selection
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