BCL11B Antibody - middle region : Biotin (ARP33293_P050-Biotin)

Product Specifications

Gene Name

B-cell CLL/lymphoma 11B (zinc finger protein)

Gene Aliases

ATL1, RIT1, CTIP2, IMD49, CTIP-2, IDDFSTA, ZNF856B, ATL1-beta, ATL1-alpha, ATL1-delta, ATL1-gamma, hRIT1-alpha

Gene ID

64919

Swiss Prot

Q9C0K0-2

Accession Number

NP_075049

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human BCL11B

Target

BCL11B is the tumor-suppressor protein involved in T-cell lymphomas. BCL11B may function on the P53-signaling pathway. BCL11B may be a key regulator of both differentiation and survival during thymocyte development. BCL11B repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.

Partner Proteins

HDAC6; HDAC2; HDAC1; NOTCH1; UBC; HDAC3; SUV39H1; tat; CBX5; NR2F1; SP1; MBD3; MTA2; MTA1; RBBP7; RBBP4; CHD4; NR2F2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.