PRDM16 Antibody - middle region: FITC (ARP33260_P050-FITC)
Product Specifications
Gene Name
PR domain containing 16
Gene Aliases
MEL1, KMT8F, LVNC8, PFM13, CMD1LL
Gene ID
63976
Swiss Prot
Q9HAZ2
Accession Number
NP_071397
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human PRDM16
Target
The reciprocal translocation t (1;3) (p36; q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) . This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t (1:3) (p36, q21) -positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Partner Proteins
TFAP4; UBC; HDAC2; Ctbp2; SUMO1; SKI; SMAD3; SMAD2; INADL
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 92%; Dog: 77%; Guinea Pig: 86%; Horse: 85%; Human: 100%; Mouse: 79%; Pig: 92%; Rat: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
140kDa
Shipping Conditions
Wet Ice
Protein Length
1275
NCBI Gene Symbol
PRDM16
Protein Name
PR domain zinc finger protein 16
Nucleotide Accession Number
NM_022114
Curated Selection
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