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HS3ST1 Antibody - middle region : HRP (ARP33092_P050-HRP)

Product Specifications

Gene Name

Heparan sulfate (glucosamine) 3-O-sulfotransferase 1

Gene Aliases

3OST, 3OST1

Gene ID

9957

Swiss Prot

O14792

Accession Number

NP_005105

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human HS3ST1

Target

HS3ST1 is the rate limiting enzyme for synthesis of HSact. HS3ST1 performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (HSact) that is to complete the structure of the antithrombin pentasaccharide binding site.Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.

Partner Proteins

LGR4; APP; UBC

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

34kDa

References & Citations

Edavettal, S.C., (2004) Biochemistry 43 (16), 4680-4688

Shipping Conditions

Wet Ice

Product Datasheet

Anti-HS3ST1 (ARP33092_P050-HRP) antibody

Protein Length

307

NCBI Gene Symbol

HS3ST1

NCBI GB Accession Number

HS3ST1

Host or Source

Rabbit

Protein Name

Heparan sulfate glucosamine 3-O-sulfotransferase 1

Nucleotide Accession Number

NM_005114

Peptide Sequence

TKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELV

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