PLCG1 Antibody - C-terminal region: Biotin (ARP33086_P050-Biotin)

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor) -activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

EGFR; UBC; SARNP; WDR61; RIC8A; AASDHPPT; UBR7; EHD4; DPP7; GTF3C4; LIMD1; RPL38; PYGB; ZAP70; KHDRBS1; RASA1; JAK2; JAK1; LCP2; ERBB3; ERBB2; CBL; LAT; VAV1; PDGFRB; INSR; IRS2; NTMT1; SPRY1; NPM1; NCAM1; ALK; PML; IBTK; EEF1A1; BLNK; BAG3; EPOR; CAMK2A

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.