POU4F3 Antibody - middle region : Biotin (ARP33065_T100-Biotin)
Selected Variant
ARP33065_T100-Biotin
Size: 100 µL
Product Specifications
Gene Name
POU class 4 homeobox 3
Gene Aliases
BRN3C, DFNA15, DFNA42, DFNA52
Gene ID
5459
Swiss Prot
Q15319
Accession Number
NP_002691
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human POU4F3
Target
POU4F3 is capable of activating both BDNF and NT-3 promoters in inner ear sensory epithelial cell lines. Mutant POU4F3 loses most of its transcriptional activity and most of its ability to bind to DNA. The mutation causes autosomal-dominant nonsyndromic hearing loss and eventually leads to hair cell morbidity in affected family members.
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
37kDa
References & Citations
Weiss, S., et al., (2003) Mol. Cell. Biol. 23 (22), 7957-7964
Shipping Conditions
Wet Ice
Protein Length
338
NCBI Gene Symbol
POU4F3
NCBI GB Accession Number
POU4F3
Host or Source
Rabbit
Protein Name
POU domain, class 4, transcription factor 3
Nucleotide Accession Number
NM_002700
Peptide Sequence
ALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYR
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