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APTX Antibody - middle region : Biotin (ARP32885_P050-Biotin)

Product Specifications

Gene Name

Aprataxin

Gene Aliases

AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT

Gene ID

54840

Swiss Prot

Q5T782

Accession Number

NP_778239

Host

Rabbit

Reactivity

Human, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human APTX

Target

APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined. This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.

Partner Proteins

PNMA1; UBC; SUMO1; NEDD8; LIG3; HSPA4; XRCC1; DDX21; CNTROB; TSPYL2; CALCOCO1; SYT17; ZNF639; MAPKBP1; CEP350; PICK1; XRCC4; TRIM37; MBP; HIVEP1; BANF1; PARP1; TP53

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

APTX is supported by BioGPS gene expression data to be expressed in HEK293T, HepG2

Concentration

0.5 mg/ml

Homology

Cow: 77%; Dog: 86%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Rabbit: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

35kDa

References & Citations

Yoon, G., (2008) J. Neurol. Neurosurg. Psychiatr. 79 (2), 234-236

Shipping Conditions

Wet Ice

Protein Length

306

NCBI Gene Symbol

APTX

NCBI GB Accession Number

APTX

Host or Source

Rabbit

Protein Name

Aprataxin

Nucleotide Accession Number

NM_175069

Peptide Sequence

YPYIVEFEEEAKNPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSN

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