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APTX Antibody - middle region : FITC (ARP32885_P050-FITC)

Product Specifications

Gene Name

Aprataxin

Gene Aliases

AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT

Gene ID

54840

Swiss Prot

Q5T782

Accession Number

NP_778239

Host

Rabbit

Reactivity

Human, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human APTX

Target

APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined. This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.

Partner Proteins

PNMA1; UBC; SUMO1; NEDD8; LIG3; HSPA4; XRCC1; DDX21; CNTROB; TSPYL2; CALCOCO1; SYT17; ZNF639; MAPKBP1; CEP350; PICK1; XRCC4; TRIM37; MBP; HIVEP1; BANF1; PARP1; TP53

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

APTX is supported by BioGPS gene expression data to be expressed in HEK293T, HepG2

Concentration

0.5 mg/ml

Homology

Cow: 77%; Dog: 86%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Rabbit: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

35kDa

References & Citations

Yoon, G., (2008) J. Neurol. Neurosurg. Psychiatr. 79 (2), 234-236

Shipping Conditions

Wet Ice

Protein Length

306

NCBI Gene Symbol

APTX

NCBI GB Accession Number

APTX

Host or Source

Rabbit

Protein Name

Aprataxin

Nucleotide Accession Number

NM_175069

Peptide Sequence

YPYIVEFEEEAKNPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSN

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