PPARG Antibody - N-terminal region : Biotin (ARP32879_P050-Biotin)

PPARG is a receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPARG is the key regulator of adipocyte differentiation and glucose homeostasis.This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

HDAC3; NCOA1; NCOA3; SUMO1; UBC; SUMO2; RXRA; MED1; HMGA1; EP300; NCOA2; CDC34; PRKAA2; PRKAA1; PPARGC1A; ASH2L; RBBP5; NSD1; NCOA6; PAXIP1; MUC1; NR3C1; SMAD2; CREBBP; ALOX15B; ZFYVE9; USP7; NCOR1; CDK5; SMARCD3; SMARCA4; NEDD4; BCAS2; MIF4GD; MED14; JAZ

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.