PHB Antibody - C-terminal region : Biotin (ARP32807_P050-Biotin)

Product Specifications

Gene Name

Prohibitin

Gene Aliases

PHB1, HEL-215, HEL-S-54e

Gene ID

5245

Swiss Prot

P35232

Accession Number

NP_002625

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PHB

Target

Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

Partner Proteins

FUS; HUWE1; SUMO2; SPRTN; STAU1; MDM2; SUZ12; EED; RNF2; PARP1; NAP1L1; COX6C; LONRF3; FBXO6; ADRB2; HDAC5; RAF1; KRAS; RAPH1; IPO11; SMG5; YWHAZ; YWHAB; VDAC2; RPS4X; RPL7; PRKCD; PLEC; NPM1; LMNA; IGHG1; HSP90AB1; GTF3C1; DBN1; COL9A2; CAPZA1; SLC25A5

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Sample Type

PHB is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

30kDa

References & Citations

Fraering, P.C., et al., (2004) Biochemistry 43 (30), 9774-9789

Shipping Conditions

Wet Ice

Protein Length

272

NCBI Gene Symbol

PHB

NCBI GB Accession Number

PHB

Host or Source

Rabbit

Protein Name

Prohibitin

Nucleotide Accession Number

NM_002634

Peptide Sequence

AEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLS

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