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PDK4 Antibody - N-terminal region : Biotin (ARP32787_P050-Biotin)

Product Specifications

Gene Name

Pyruvate dehydrogenase kinase, isozyme 4

Gene Aliases

FLJ40832

Gene ID

5166

Swiss Prot

Q16654

Accession Number

NP_002603

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PDK4

Target

PDK4 is a member of the PDK/BCKDK protein kinase family and is a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism.This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

Partner Proteins

UBC; DLAT; PDK4; PDHA1; TRIM63

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 92%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 100%; Rat: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

46kDa

References & Citations

Kimura, K., (2006) Genome Res. 16 (1), 55-65

Shipping Conditions

Wet Ice

Protein Length

411

NCBI Gene Symbol

PDK4

NCBI GB Accession Number

PDK4

Host or Source

Rabbit

Protein Name

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial

Nucleotide Accession Number

NM_002612

Peptide Sequence

MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACE

Frequently Asked Questions

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