Smad6 Antibody - C-terminal region : Biotin (ARP32689_P050-Biotin)
Selected Variant
ARP32689_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
SMAD family member 6
Gene Aliases
Madh, Madh6, b2b390C, b2b390Clo
Gene ID
17130
Swiss Prot
O35182
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of MOUSE Smad6
Target
Smad6 binds to regulatory elements in target promoter regions. It may block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. It acts as a mediator of TGF-beta and BMP antiflammatory activity. It suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
Partner Proteins
Smurf1; Tbx6; Bmpr2; Bmpr1a; Acvr1; Runx2; tob1a; Axin1; SMURF2; BMPR1B
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
54kDa
Shipping Conditions
Wet Ice
Protein Length
459
NCBI Gene Symbol
SMAD6
NCBI GB Accession Number
Smad6
Host or Source
Rabbit
Protein Name
Mothers against decapentaplegic homolog 6
Peptide Sequence
PDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGL
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