AIRE Antibody - N-terminal region : Biotin (ARP32649_P050-Biotin)

Product Specifications

Gene Name

Autoimmune regulator

Gene Aliases

APS1, APSI, PGA1, AIRE1, APECED

Gene ID

326

Swiss Prot

O43918

Accession Number

NP_000374

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE

Target

The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) .

Partner Proteins

TUBB; RAVER1; TUBA1C; TMPRSS13; CCDC87; FAT1; GIGYF2; SRRM2; TUBB4B; EIF4EBP3; UBB; HSP90AB1; HSPA8; HSPA5; HSPA1L; HSPA1A; ATP4A; HIST3H3; HDAC2; HDAC1; DAXX; AIRE; UBAC1; HIST1H3A; HIST2H2BE; HSPA4; SRSF1; SMC1A; XPO1; TOP2A; SSRP1; SNRPD3; SNRPB; SRSF3

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 79%; Dog: 92%; Horse: 86%; Human: 100%; Pig: 93%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.