AIRE Antibody - N-terminal region : HRP (ARP32649_P050-HRP)
Selected Variant
ARP32649_P050-HRP
Size: 100 µL
Product Specifications
Gene Name
Autoimmune regulator
Gene Aliases
APS1, APSI, PGA1, AIRE1, APECED
Gene ID
326
Swiss Prot
O43918
Accession Number
NP_000374
Host
Rabbit
Reactivity
Human, Rat, Cow, Dog, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
Target
The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) .
Partner Proteins
TUBB; RAVER1; TUBA1C; TMPRSS13; CCDC87; FAT1; GIGYF2; SRRM2; TUBB4B; EIF4EBP3; UBB; HSP90AB1; HSPA8; HSPA5; HSPA1L; HSPA1A; ATP4A; HIST3H3; HDAC2; HDAC1; DAXX; AIRE; UBAC1; HIST1H3A; HIST2H2BE; HSPA4; SRSF1; SMC1A; XPO1; TOP2A; SSRP1; SNRPD3; SNRPB; SRSF3
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 79%; Dog: 92%; Horse: 86%; Human: 100%; Pig: 93%; Rat: 79%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
58kDa
References & Citations
Akiyoshi, H., et al., (2004) J. Biol. Chem. 279 (32), 33984-33991
Shipping Conditions
Wet Ice
Protein Length
545
NCBI Gene Symbol
AIRE
NCBI GB Accession Number
AIRE
Host or Source
Rabbit
Protein Name
Autoimmune regulator
Nucleotide Accession Number
NM_000383
Peptide Sequence
DFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPP
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