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HDAC2 Antibody - C-terminal region : HRP (ARP32618_P050-HRP)

Selected Variant

ARP32618_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Histone deacetylase 2

Gene Aliases

HD2, RPD3, YAF1, KDAC2

Gene ID

3066

Swiss Prot

Q92769

Accession Number

NP_001518

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC2

Target

Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human.

Partner Proteins

BRCA1; SUMO1; UBC; SMAD7; SMAD2; MXD1; NCOR2; SUMO2; SFPQ; KDM5A; HDAC1; DDB1; CUL4B; CHFR; KDM1A; KDM5B; NFE2L2; PRDM6; DNMT3B; DNMT1; NACC2; HIST1H4A; HIST1H3A; HIST2H2BE; HIST2H2AC; PRDM1; EED; RNF2; SP1; CHD4; CHD3; ACTL6A; C16orf87; HMG20A; HMG20B; C

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Yeast: 91%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

55kDa

References & Citations

Choi, Y.B., et al., (2004) J.Biol.Chem.279 (49),50930-50941

Shipping Conditions

Wet Ice

Protein Length

488

NCBI Gene Symbol

HDAC2

NCBI GB Accession Number

HDAC2

Host or Source

Rabbit

Protein Name

Histone deacetylase 2

Nucleotide Accession Number

NM_001527

Peptide Sequence

EEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSK

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