TBX21 Antibody - middle region : Biotin (ARP32612_P050-Biotin)
Product Specifications
Gene Name
T-box 21
Gene Aliases
TBET, T-PET, T-bet, TBLYM
Gene ID
30009
Swiss Prot
Q9UL17
Accession Number
NP_037483
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human TBX21
Target
TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. It is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG) . Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
Partner Proteins
USP10; UBC; EXOC5; ZNF490; SP1; HOXC11; GATA3; EP300; CREBBP
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 86%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 86%; Rat: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
58kDa
References & Citations
Sasaki, Y., et al., (2004) Hum. Genet. 115 (3), 177-184
Shipping Conditions
Wet Ice
Protein Length
535
NCBI Gene Symbol
TBX21
NCBI GB Accession Number
TBX21
Host or Source
Rabbit
Protein Name
T-box transcription factor TBX21
Nucleotide Accession Number
NM_013351
Peptide Sequence
SIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWL
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