NCOR1 Antibody - N-terminal region : Biotin (ARP32479_P050-Biotin)
Selected Variant
ARP32479_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
Nuclear receptor corepressor 1
Gene Aliases
N-CoR, TRAC1, N-CoR1, hN-CoR, PPP1R109
Gene ID
9611
Swiss Prot
Q60974
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Yeast
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR1
Target
NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p.
Partner Proteins
RARA; TP53; ESR1; PHB2; ZBTB16; THRB; THRA; CREB1; JUN; PPARG; SQSTM1; HDAC3; UBE2I; SOX2; HDAC7; HDAC5; HDAC4; UBC; SKIL; SKI; AR; SMAD4; CSNK2A1; RUNX1T1; CXADR; TBL1XR1; vif; C1D; CHUK; YWHAZ; SMARCE1; SMARCD1; SMARCA2; RBBP4; BPTF; HMGXB4; TAB2; NCOR2
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Mouse: 100%; Rat: 92%; Yeast: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
270kDa
References & Citations
Horlein, A.J., et al., (1995) Nature 377 (6548), 397-404
Shipping Conditions
Wet Ice
Protein Length
2453
NCBI Gene Symbol
NCOR1
NCBI GB Accession Number
NCOR1
Host or Source
Rabbit
Protein Name
Nuclear receptor corepressor 1
Peptide Sequence
NENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKK
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