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NCOR2 Antibody - N-terminal region : FITC (ARP32463_P050-FITC)

Product Specifications

Gene Name

Nuclear receptor corepressor 2

Gene Aliases

SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270, SMRTE-tau

Gene ID

9612

Swiss Prot

Q9Y618

Accession Number

NP_006303

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Pig, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR2

Target

NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

Partner Proteins

HDAC4; HDAC3; RARA; HMGA1; HDAC2; HDAC1; AURKA; BCL6; BCOR; GPS2; ZBTB16; UBC; E2F1; NR1I2; BTRC; HDAC7; NR1H2; THRA; RUNX1; Pparg; Nr2f1; Nr1i3; Nr2f2; CBX6; C1D; NR1H4; NR1D1; Ppard; SUMO2; CTBP1; ARNT; AHR; NCOR1; AR; NRD1; E2F4; ZBTB7A; SOX2; ESR1; CE

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

NCOR2 is supported by BioGPS gene expression data to be expressed in HeLa

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Human: 100%; Mouse: 86%; Pig: 100%; Rat: 86%; Yeast: 87%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

275kDa

References & Citations

Keeton, E.K. (2005) Mol. Endocrinol. 19 (6), 1543-1554

Shipping Conditions

Wet Ice

Protein Length

2524

NCBI Gene Symbol

NCOR2

NCBI GB Accession Number

NCOR2

Host or Source

Rabbit

Protein Name

Nuclear receptor corepressor 2

Nucleotide Accession Number

NM_006312

Peptide Sequence

PMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDE

Frequently Asked Questions

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