CHD3 Antibody : FITC (ARP32459_P050-FITC)

Product Specifications

Gene Name

Chromodomain helicase DNA binding protein 3

Gene Aliases

ZFH, Mi-2a, SNIBCPS, Mi2-ALPHA

Gene ID

1107

Swiss Prot

Q12873

Accession Number

NP_005843

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the following sequence EFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDG

Target

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Partner Proteins

TRIM28; SUMO2; UBC; LGR4; RNF2; BMI1; SOX2; HDAC2; HDAC1; SIRT1; SKIL; HDAC3; SMARCC2; RBBP7; RBBP4; CHD4; GATAD2A; MBD3; MTA2; IKZF1; GIT1; ZHX1; IMMT; TCERG1; VIM; TP53; TAL1; PTN; NEFL; KPNB1; PIAS4; LRIF1; PRPF40A; HTT; CHD3; BARD1; TWIST1; KDM1A; KDM

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.