POLR2B Antibody - N-terminal region : Biotin (ARP32457_T100-Biotin)
Product Specifications
Gene Name
Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Gene Aliases
RPB2, POL2RB, hRPB140
Gene ID
5431
Swiss Prot
P30876
Accession Number
NP_000929
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human POLR2B
Target
POLR2B is the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.
Partner Proteins
ESR1; UBC; TCEB3; SRC; PSMB9; SUMO2; XRN2; WWOX; SUZ12; RNF2; NEDD4; ITCH; RABEP2; HECW2; FBXO6; CDK20; HDAC11; ILK; POLR2C; MED19; MED26; RECQL5; VCP; BARD1; MDC1; POLR3F; TUBB4B; TUBA4A; POLR2I; POLR2E; POLR2D; POLR2A; DCTN1; ATP6V1B2; MEN1; CDK7; CCNH
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
134kDa
References & Citations
Langelier, M.F., et al., (2005) (er) Nucleic Acids Res. 33 (8), 2629-2639
Shipping Conditions
Wet Ice
Protein Length
1174
NCBI Gene Symbol
POLR2B
NCBI GB Accession Number
POLR2B
Host or Source
Rabbit
Protein Name
DNA-directed RNA polymerase II subunit RPB2
Nucleotide Accession Number
NM_000938
Peptide Sequence
TYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTD
Subunit
RPB2
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