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SIRT2 Antibody - C-terminal region : HRP (ARP32385_P050-HRP)

Selected Variant

ARP32385_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Sirtuin 2

Gene Aliases

SIR2, SIR2L, SIR2L2

Gene ID

22933

Swiss Prot

Q8IXJ6

Accession Number

NP_085096

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human SIRT2

Target

SIRT2 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT2 is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.

Partner Proteins

ACLY; SIRT1; UBC; ING1; EP300; CBLB; CBL; XPO1; CDC20; FZR1; RUNX3; PCK1; FOXO1; HDAC6; tat; RBP1; HIST1H3A; NUDT21; PAPOLA; DNAJB8; DNAJB6; SP140; KAT2B; CDC14B; KAT2A; TUBA4A; HOXA10; TUBB; KRT78; RTN4; PHB2; SPOP; ELL; SARS; GYS1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Rabbit: 79%; Rat: 93%; Zebrafish: 75%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

40kDa

References & Citations

Borra, M.T., et al., (2004) Biochemistry 43 (30), 9877-9887

Shipping Conditions

Wet Ice

Protein Length

352

NCBI Gene Symbol

SIRT2

NCBI GB Accession Number

SIRT2

Host or Source

Rabbit

Protein Name

NAD-dependent protein deacetylase sirtuin-2

Nucleotide Accession Number

NM_030593

Peptide Sequence

DVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTS

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