SIRT2 Antibody - C-terminal region : FITC (ARP32385_P050-FITC)
Product Specifications
Gene Name
Sirtuin 2
Gene Aliases
SIR2, SIR2L, SIR2L2
Gene ID
22933
Swiss Prot
Q8IXJ6
Accession Number
NP_085096
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human SIRT2
Target
SIRT2 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT2 is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.
Partner Proteins
ACLY; SIRT1; UBC; ING1; EP300; CBLB; CBL; XPO1; CDC20; FZR1; RUNX3; PCK1; FOXO1; HDAC6; tat; RBP1; HIST1H3A; NUDT21; PAPOLA; DNAJB8; DNAJB6; SP140; KAT2B; CDC14B; KAT2A; TUBA4A; HOXA10; TUBB; KRT78; RTN4; PHB2; SPOP; ELL; SARS; GYS1
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 86%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Rabbit: 79%; Rat: 93%; Zebrafish: 75%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
40kDa
References & Citations
Borra, M.T., et al., (2004) Biochemistry 43 (30), 9877-9887
Shipping Conditions
Wet Ice
Protein Length
352
NCBI Gene Symbol
SIRT2
NCBI GB Accession Number
SIRT2
Host or Source
Rabbit
Protein Name
NAD-dependent protein deacetylase sirtuin-2
Nucleotide Accession Number
NM_030593
Peptide Sequence
DVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTS
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