TLE1 Antibody - N-terminal region : Biotin (ARP32359_P050-Biotin)

Product Specifications

Gene Name

Transducin-like enhancer of split 1 (E (sp1) homolog, Drosophila)

Gene Aliases

ESG, ESG1, GRG1

Gene ID

7088

Swiss Prot

Q04724

Accession Number

NP_005068

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human TLE1

Target

TLE1 is a transcriptional corepressor that binds to a number of transcription factors. TLE1 inhibits NF-kappa-B-regulated gene expression and the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE1 has an unusual function as coactivator for ESRRG.

Partner Proteins

TLE1; TCF3; TCF4; UBC; SS18; SSX2; HDAC1; EZH2; ATF2; APH1A; LEF1; TLX3; PROP1; HES1; TLX1; HHEX; FOXG1; ESRRG; EN1; tcf7l1a; NOD2; AES; HESX1; GSK3B; GRB7; NUDT21; DAZAP2; KIAA0408; TSC22D1; TK1; SMN1; RAP1B; GADD45A; CSNK2B; RCC1; CDKN1A; BID; BCL2L1; A

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.