ZUP1 Antibody - middle region : Biotin (ARP32274_P050-Biotin)
Product Specifications
Gene Name
Zinc finger containing ubiquitin peptidase 1
Gene Aliases
DUB, ZUFSP, C6orf113
Gene ID
221302
Swiss Prot
Q96AP4
Accession Number
NP_659499
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human C6orf113
Target
This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers.
Partner Proteins
UBC; RPS21; PRMT5; CLN8; SHCBP1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
66kDa
References & Citations
Mungall, A.J., (2003) Nature 425 (6960), 805-811
Shipping Conditions
Wet Ice
Protein Length
578
NCBI Gene Symbol
ZUP1
NCBI GB Accession Number
ZUP1
Host or Source
Rabbit
Protein Name
Zinc finger-containing ubiquitin peptidase 1
Nucleotide Accession Number
NM_145062
Peptide Sequence
RQEIEEFQKLQRQYGLDNSGGYKQQQLRNMEIEVNRGRMPPSEFHRRKAD
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