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ZUP1 Antibody - middle region : HRP (ARP32274_P050-HRP)

Selected Variant

ARP32274_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Zinc finger containing ubiquitin peptidase 1

Gene Aliases

DUB, ZUFSP, C6orf113

Gene ID

221302

Swiss Prot

Q96AP4

Accession Number

NP_659499

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human C6orf113

Target

This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers.

Partner Proteins

UBC; RPS21; PRMT5; CLN8; SHCBP1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

66kDa

References & Citations

Mungall, A.J., (2003) Nature 425 (6960), 805-811

Shipping Conditions

Wet Ice

Protein Length

578

NCBI Gene Symbol

ZUP1

NCBI GB Accession Number

ZUP1

Host or Source

Rabbit

Protein Name

Zinc finger-containing ubiquitin peptidase 1

Nucleotide Accession Number

NM_145062

Peptide Sequence

RQEIEEFQKLQRQYGLDNSGGYKQQQLRNMEIEVNRGRMPPSEFHRRKAD

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