EPAS1 Antibody - middle region : Biotin (ARP32253_P050-Biotin)

Product Specifications

Gene Name

Endothelial PAS domain protein 1

Gene Aliases

HLF, MOP2, ECYT4, HIF2A, PASD2, bHLHe73

Gene ID

2034

Swiss Prot

Q99814

Accession Number

NP_001421

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human EPAS1

Target

EPAS1 is a transcription factor involved in the induction of oxygen regulated genes. EPAS1 binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. EPAS1 regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. EPAS1 may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. EPAS1 is a potent activator of the Tie-2 tyrosine kinase expression. The activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction of EPAS1 with redox regulatory protein APEX seems to activate CTAD.

Partner Proteins

MAP1LC3A; SQSTM1; LAMP1; BATF2; BATF3; BATF; DDIT3; DBP; NDN; JUN; EPAS1; NPM1; BBS4; BBS2; BBS1; Arnt; VHL; STAT5A; SMAD3; EWSR1; MED11; MED8; EGLN3; PSMD1; PSMB1; MED1; PHB; MITF; HIF1A; EP300; EMD; CTNNB1; CREBBP; EGLN2; DPY30; MED10; MED25; ARID1B; WR

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.