EPAS1 Antibody - middle region: HRP (ARP32253_P050-HRP)
Product Specifications
Gene Name
Endothelial PAS domain protein 1
Gene Aliases
HLF, MOP2, ECYT4, HIF2A, PASD2, bHLHe73
Gene ID
2034
Swiss Prot
Q99814
Accession Number
NP_001421
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human EPAS1
Target
EPAS1 is a transcription factor involved in the induction of oxygen regulated genes. EPAS1 binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. EPAS1 regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. EPAS1 may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. EPAS1 is a potent activator of the Tie-2 tyrosine kinase expression. The activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction of EPAS1 with redox regulatory protein APEX seems to activate CTAD.
Partner Proteins
MAP1LC3A; SQSTM1; LAMP1; BATF2; BATF3; BATF; DDIT3; DBP; NDN; JUN; EPAS1; NPM1; BBS4; BBS2; BBS1; Arnt; VHL; STAT5A; SMAD3; EWSR1; MED11; MED8; EGLN3; PSMD1; PSMB1; MED1; PHB; MITF; HIF1A; EP300; EMD; CTNNB1; CREBBP; EGLN2; DPY30; MED10; MED25; ARID1B; WR
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
90kDa
Shipping Conditions
Wet Ice
Protein Length
870
NCBI Gene Symbol
EPAS1
Protein Name
Endothelial PAS domain-containing protein 1
Nucleotide Accession Number
NM_001430
Curated Selection
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