DVL1 Antibody - C-terminal region : Biotin (ARP32101_T100-Biotin)

DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.

NCK2; TRIM69; NUMA1; HUWE1; UBC; DVL2; WWOX; SIPA1; PSMA3; LRRK2; ITCH; HECW1; NEDD4; ANXA7; SDC4; NKD2; CYLD; SIRT1; CCDC88C; VANGL1; CXXC4; PPM1A; DYNLT1; HDHD2; BRD7; DAAM1; AXIN1; USP13; SMAD3; SMAD7; FRAT1; RAC1; DVL3; SMAD2; DVL1; SMAD4; CSNK1D; CSN

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.