SMAD7 Antibody - N-terminal region : HRP (ARP32008_P050-HRP)
Selected Variant
ARP32008_P050-HRP
Size: 100 µL
Product Specifications
Gene Name
SMAD family member 7
Gene Aliases
CRCS3, MADH7, MADH8
Gene ID
4092
Swiss Prot
O15105
Accession Number
NP_005895
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD7
Target
Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
Partner Proteins
HDAC3; HDAC2; USP11; SMURF2; SMURF1; SKP2; MYC; Melk; HCVgp1; RNF111; KDM2A; SOX13; PIAS1; SOX7; UBE2O; MKL2; ASH1L; PIAS4; CXXC5; ZNF107; ZBTB11; HEYL; TTF2; UBC; TTF1; SOX5; MYOD1; XRCC6; CTNNB1; MAPK14; BAMBI; PPP1R15A; NEDD4L; STAMBP; YAP1; AXIN1; TP5
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 93%; Human: 100%; Mouse: 92%; Pig: 93%; Rabbit: 93%; Rat: 85%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
46kDa
References & Citations
Komuro, A., et al., (2004) Oncogene 23 (41), 6914-6923
Shipping Conditions
Wet Ice
Protein Length
426
NCBI Gene Symbol
SMAD7
NCBI GB Accession Number
SMAD7
Host or Source
Rabbit
Protein Name
Mothers against decapentaplegic homolog 7
Nucleotide Accession Number
NM_005904
Peptide Sequence
EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHH
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