SMAD4 Antibody - middle region: Biotin (ARP32005_T100-Biotin)
Product Specifications
Gene Name
SMAD family member 4
Gene Aliases
JIP, DPC4, MADH4, MYHRS
Gene ID
4089
Swiss Prot
Q13485
Accession Number
NP_005350
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SMAD4
Target
SMAD4 is one of the Smad family members, which are essential intracellular signalling components of the transforming growth factor-beta (TGF-beta) superfamily. Smad2 and Smad3 are structurally highly similar and mediate TGF-beta signals. Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction
Partner Proteins
RASSF5; LMO4; SMAD3; SMAD2; SKIL; UBC; NEDD8; SUMO1; SMURF2; SMURF1; TRIM33; CRYAB; COPS5; NLK; OTUB1; SMAD9; UBE2I; FHL3; FHL2; FHL1; CSNK1D; TGFB1I1; SMAD1; NCOR1; SKI; KLF5; IRF7; IRF3; ZNF521; ZNF423; SOX12; SNRNP70; RPL28; RFX1; RELA; RALA; PSMD11; P
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 92%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%; Sheep: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
60kDa
Shipping Conditions
Wet Ice
Protein Length
552
NCBI Gene Symbol
SMAD4
Protein Name
Mothers against decapentaplegic homolog 4
Nucleotide Accession Number
NM_005359
Curated Selection
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