SMAD4 Antibody - middle region : Biotin (ARP32005_T100-Biotin)
Product Specifications
Gene Name
SMAD family member 4
Gene Aliases
JIP, DPC4, MADH4, MYHRS
Gene ID
4089
Swiss Prot
Q13485
Accession Number
NP_005350
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SMAD4
Target
SMAD4 is one of the Smad family members, which are essential intracellular signalling components of the transforming growth factor-beta (TGF-beta) superfamily. Smad2 and Smad3 are structurally highly similar and mediate TGF-beta signals. Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction
Partner Proteins
RASSF5; LMO4; SMAD3; SMAD2; SKIL; UBC; NEDD8; SUMO1; SMURF2; SMURF1; TRIM33; CRYAB; COPS5; NLK; OTUB1; SMAD9; UBE2I; FHL3; FHL2; FHL1; CSNK1D; TGFB1I1; SMAD1; NCOR1; SKI; KLF5; IRF7; IRF3; ZNF521; ZNF423; SOX12; SNRNP70; RPL28; RFX1; RELA; RALA; PSMD11; P
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 92%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%; Sheep: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
60kDa
References & Citations
Kantola, A.K., et al., Gene 363, 142-150 (2005)
Shipping Conditions
Wet Ice
Protein Length
552
NCBI Gene Symbol
SMAD4
NCBI GB Accession Number
SMAD4
Host or Source
Rabbit
Protein Name
Mothers against decapentaplegic homolog 4
Nucleotide Accession Number
NM_005359
Peptide Sequence
NIPVASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNST
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