AIRE Antibody - middle region : HRP (ARP31969_P050-HRP)

The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) .This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD) . Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) .

TUBB; RAVER1; TUBA1C; TMPRSS13; CCDC87; FAT1; GIGYF2; SRRM2; TUBB4B; EIF4EBP3; UBB; HSP90AB1; HSPA8; HSPA5; HSPA1L; HSPA1A; ATP4A; HIST3H3; HDAC2; HDAC1; DAXX; AIRE; UBAC1; HIST1H3A; HIST2H2BE; HSPA4; SRSF1; SMC1A; XPO1; TOP2A; SSRP1; SNRPD3; SNRPB; SRSF3

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.