Bilastine

Bilastine is an oral histamine H1-receptor antagonist. Bilastine can be used for allergic rhinitis and urticaria studies, and it also improves diabetic nephropathy in mice, showing safety for the central nervous system[1][2][3][4].

Product Specifications

CAS Number

[202189-78-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Bilastine.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C)(C1=CC=C(CCN2CCC(C3=NC4=CC=CC=C4N3CCOCC)CC2)C=C1)C(O)=O

Molecular Formula

C28H37N3O3

Molecular Weight

463.61

Precautions

H302

References & Citations

[1]C. Bachert, et al. Bilastine in allergic rhinoconjunctivitis and urticaria. Allergy.19 May 2010|[2]María Luisa Lucero, et al. Preclinical toxicity profile of oral bilastine. Drug Chem Toxicol. 2012 Jun:35 Suppl 1:25-33.|[3]Roberta Verta, et al. Effect of Bilastine on Diabetic Nephropathy in DBA2/J Mice. Int J Mol Sci. 2019 May 24;20 (10) :2554.|[4]J Montoro, et al. Bilastine and the central nervous system. J Investig Allergol Clin Immunol. J Investig Allergol Clin Immuno