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FGD1 Antibody - C-terminal region : Biotin (ARP31673_P050-Biotin)

Selected Variant

ARP31673_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

FYVE, RhoGEF and PH domain containing 1

Gene Aliases

AAS, FGDY, MRXS16, ZFYVE3

Gene ID

2245

Swiss Prot

P98174

Accession Number

NP_004454

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human FGD1

Target

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

Partner Proteins

BTRC; UBC; ELAVL1; ELMO1; CTTN; CDC42; AOC1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

FGD1 is supported by BioGPS gene expression data to be expressed in Raji

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Horse: 79%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 79%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

107kDa

References & Citations

Lebel, R.R., et al., (2002) Clin. Genet. 61 (2), 139-145

Shipping Conditions

Wet Ice

Protein Length

961

NCBI Gene Symbol

FGD1

NCBI GB Accession Number

FGD1

Host or Source

Rabbit

Protein Name

FYVE, RhoGEF and PH domain-containing protein 1

Nucleotide Accession Number

NM_004463

Peptide Sequence

WMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDKT

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