NFYA Antibody - C-terminal region : Biotin (ARP31380_P050-Biotin)

Product Specifications

Gene Name

Nuclear transcription factor Y, alpha

Gene Aliases

HAP2, CBF-A, CBF-B, NF-YA

Gene ID

4800

Swiss Prot

P23511

Accession Number

NP_002496

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human NFYA

Target

NFYA is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

Partner Proteins

LUC7L2; POGZ; NFYB; GTF2A1; CSNK2A1; UBC; APPBP2; TP63; TP53; NFYC; EP300; CDK2; CCNA2; CDC25A; APP; RPS6KA6; JUN; HDAC1; ATF2; SP1; TAF6; TAF11; TAF12; PAPOLG; PWP1; SREBF2; ZHX2; ZHX1; ZHX3; KPNB1; SRSF1; HMGA1; SRF; USF2; USF1; NFYA; NR5A1; POU2F1; CEB

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

NFYA is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.