CCNH Antibody - N-terminal region: Biotin (ARP31337_P050-Biotin)
Product Specifications
Gene Name
Cyclin H
Gene Aliases
CAK, p34, p37, CycH
Gene ID
902
Swiss Prot
P51946
Accession Number
NP_001230
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human CCNH
Target
Cyclin H regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. It is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Partner Proteins
SFN; GOLGA2; SSX2IP; CCDC170; CCDC33; DUSP12; SSSCA1; NDC80; CALCOCO2; PPFIA1; PSMA1; KLC3; RPA3; RPA2; RPA1; NEDD4; CDK7; CDK8; CDK2; CCNC; MNAT1; MBP; CTD; CDK20; CTBP2; CSNK2B; TRIM8; GANAB; RARB; POLR2A; GTF2H4; ERCC2; tat; POLR2B; CDK9; BRCA1; GTF2H1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
CCNH is supported by BioGPS gene expression data to be expressed in HeLa
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
38kDa
Shipping Conditions
Wet Ice
Protein Length
323
NCBI Gene Symbol
CCNH
Protein Name
Cyclin-H
Nucleotide Accession Number
NM_001239
Curated Selection
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