VDR Antibody - N-terminal region : Biotin (ARP31243_P050-Biotin)

Product Specifications

Gene Name

Vitamin D (1,25- dihydroxyvitamin D3) receptor

Gene Aliases

NR1I1, PPP1R163

Gene ID

7421

Swiss Prot

P11473

Accession Number

NP_000367

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human VDR

Target

The nuclear hormone receptor for vitamin D3 also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

Partner Proteins

MED12; MED24; BAZ1B; SMARCA4; RXRA; MED1; NCOA2; NSD1; NCOA1; SRPK1; PTPN3; Hr; NKD2; MMRN2; CDCA7L; CXXC5; UBC; RXRB; PRKCSH; PRCP; CFH; CCND3; MYC; MXD1; BRCA1; PSMC5; NCOR1; SRC; NCOA6; PPP1CC; CDK11B; NR1H2; RXRG; CASC4; GABARAPL1; GABARAPL2; CLASRP

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that VDR is expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.