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NFIL3 Antibody - middle region : Biotin (ARP31177_P050-Biotin)

Product Specifications

Gene Name

Nuclear factor, interleukin 3 regulated

Gene Aliases

E4BP4, IL3BP1, NFIL3A, NF-IL3A

Gene ID

4783

Swiss Prot

Q16649

Accession Number

NP_005375

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human NFIL3

Target

NFIL3 is a basic leucine zipper (bZIP) transcription factor that represses or activates transcription in non-osteoblastic cells. NFIL3 play a role in attenuation of PTH target gene transcription in osteoblasts. NFIL3 repression domain interacts specifically with the TBP binding repressor protein Dr1.Glucocorticoid-mediated upregulation of the bZIP transcriptional repressor gene, NFIL3, is dependent on [Ca2+]i levels, and correlates with Glucocorticoid-evoked apoptosis of Glucocorticoid-sensitive CEM-C7-14 cells. NFIL3 is involved in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E2A-HLF leads to childhood B lineage leukemia.

Partner Proteins

AMOTL2; TRAF2; MAFF; BATF; NFIL3; MAFG; DDIT3; CBX8; SUMO2; UBC; CREB3; DR1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

51kDa

References & Citations

Priceman, S.J., (2006) Biochem. Biophys. Res. Commun. 344 (2), 491-499

Shipping Conditions

Wet Ice

Protein Length

462

NCBI Gene Symbol

NFIL3

NCBI GB Accession Number

NFIL3

Host or Source

Rabbit

Protein Name

Nuclear factor interleukin-3-regulated protein

Nucleotide Accession Number

NM_005384

Peptide Sequence

GYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPV

Frequently Asked Questions

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