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AURKA Antibody - C-terminal region : HRP (ARP30876_P050-HRP)

Selected Variant

ARP30876_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Aurora kinase A

Gene Aliases

AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, PPP1R47

Gene ID

6790

Swiss Prot

O14965

Accession Number

NP_003591

Host

Rabbit

Reactivity

Human, Cow, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human AURKA

Target

AURKA is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. It is found at the centrosome in interphase cells and at the spindle poles in mitosis. This protein may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Partner Proteins

CHFR; GADD45A; RPLP2; RPLP0; RPL38; RPL30; RPL27; RPL22; RPL12; RPL11; PSMB7; PSMB5; PSMA6; PSMA5; PSMA1; MAPK6; PPP6C; PCMT1; YBX1; NPM1; NCL; MFAP4; LYZ; ILF3; ILF2; IARS; HSPD1; HSP90AB1; HSP90AA1; HSPA9; HSPA8; HSPA5; HSPA2; HSPA1A; HNRNPU; HNRNPA2B1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that AURKA is expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 80%; Human: 100%; Sheep: 80%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

46kDa

References & Citations

Ye, Y., (2008) Cancer 112 (11), 2467-2474

Shipping Conditions

Wet Ice

Protein Length

403

NCBI Gene Symbol

AURKA

NCBI GB Accession Number

AURKA

Host or Source

Rabbit

Protein Name

Aurora kinase A

Nucleotide Accession Number

NM_003600

Peptide Sequence

ARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS

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