Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

MAP3K8 Antibody - C-terminal region : Biotin (ARP30649_T100-Biotin)

Selected Variant

ARP30649_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

Mitogen-activated protein kinase kinase kinase 8

Gene Aliases

COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT

Gene ID

1326

Swiss Prot

P41279

Accession Number

NP_005195

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K8

Target

MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1) . This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.

Partner Proteins

RELA; MAP2K1; RIPK1; NFKB1; ACY3; STIP1; HSP90AA1; TAB2; TRAF6; TRAF2; CD40; TNIP2; Nedd4; MAP3K14; MAP2K4; BMPR2; CHUK; REL; AKT1; NFKB2; KSR2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 77%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

53kDa

References & Citations

Jia, Y., et al., (2005) Arch. Biochem. Biophys. 441 (1), 64-74

Shipping Conditions

Wet Ice

Protein Length

467

NCBI Gene Symbol

MAP3K8

NCBI GB Accession Number

MAP3K8

Host or Source

Rabbit

Protein Name

Mitogen-activated protein kinase kinase kinase 8

Nucleotide Accession Number

NM_005204

Peptide Sequence

PRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLY

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Neurofilament (NF-H) (Neuronal Marker) (rNF421), CF740 conjugate, 0.1mg/mL
BNC742348-100 1x 100 µL

Neurofilament (NF-H) (Neuronal Marker) (rNF421), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
NRF1 (NRF1/2608), CF405S conjugate, 0.1mg/mL
BNC042608-100 1x 100 µL

NRF1 (NRF1/2608), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
CD61 / Integrin 3 / Platelet Glycoprotein IIIa (Platelet Marker) (ITGB3/3126R), CF740 conjugate, 0.1mg/mL
BNC743126-500 1x 500 µL

CD61 / Integrin 3 / Platelet Glycoprotein IIIa (Platelet Marker) (ITGB3/3126R), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Histone H1 (Pan Nuclear Marker) (N/A), CF594 conjugate, 0.1mg/mL
BNC941816-500 1x 500 µL

Histone H1 (Pan Nuclear Marker) (N/A), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/3256), CF488A conjugate, 0.1mg/mL
BNC883256-500 1x 500 µL

E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/3256), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Cytokeratin 7 (K72.7), CF647 conjugate, 0.1mg/mL
BNC470757-100 1x 100 µL

Cytokeratin 7 (K72.7), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details