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MAP3K8 Antibody - C-terminal region : Biotin (ARP30649_T100-Biotin)

Selected Variant

ARP30649_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

Mitogen-activated protein kinase kinase kinase 8

Gene Aliases

COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT

Gene ID

1326

Swiss Prot

P41279

Accession Number

NP_005195

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K8

Target

MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1) . This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.

Partner Proteins

RELA; MAP2K1; RIPK1; NFKB1; ACY3; STIP1; HSP90AA1; TAB2; TRAF6; TRAF2; CD40; TNIP2; Nedd4; MAP3K14; MAP2K4; BMPR2; CHUK; REL; AKT1; NFKB2; KSR2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 77%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

53kDa

References & Citations

Jia, Y., et al., (2005) Arch. Biochem. Biophys. 441 (1), 64-74

Shipping Conditions

Wet Ice

Protein Length

467

NCBI Gene Symbol

MAP3K8

NCBI GB Accession Number

MAP3K8

Host or Source

Rabbit

Protein Name

Mitogen-activated protein kinase kinase kinase 8

Nucleotide Accession Number

NM_005204

Peptide Sequence

PRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLY

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