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HIF1A Antibody - N-terminal region : Biotin (ARP30572_P050-Biotin)

Product Specifications

Gene Name

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Gene Aliases

HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF-1-alpha

Gene ID

3091

Swiss Prot

Q16665

Accession Number

NP_851397

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human HIF1A

Target

Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT) . HIF1A is the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.

Partner Proteins

HDAC1; EP300; ARNTL; HDAC3; VHL; UBC; SUMO3; EGLN3; HIF1AN; SENP3; HSP90AA1; ATM; ARNT2; SART3; SUMO2; SIN3A; TRIM28; HSPA4; TRAF6; GNB2L1; EGLN1; SQSTM1; SUMO1; HEXIM1; LAMP2; HSPA8; RB1; SP1; SMAD3; MAFK; PCGF2; TCEB2; TCEB1; MAFG; HSP90AB1; DCUN1D1; RB

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 87%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

83kDa

Shipping Conditions

Wet Ice

Product Datasheet

Anti-HIF1A (ARP30572_P050-Biotin) antibody

Protein Length

735

NCBI Gene Symbol

HIF1A

NCBI GB Accession Number

HIF1A

Host or Source

Rabbit

Protein Name

Hypoxia-inducible factor 1-alpha

Nucleotide Accession Number

NM_181054

Peptide Sequence

EGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVS

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