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Hand2 Antibody - C-terminal region : Biotin (ARP30571_P050-Biotin)

Selected Variant

ARP30571_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Heart and neural crest derivatives expressed transcript 2

Gene Aliases

Hed, Th2, dHA, Ehan, Thin, bHLHa, dHAND, Ehand2, Thing2, bHLHa26, AI225906, AI661148

Gene ID

15111

Swiss Prot

Q61039

Accession Number

NP_034532

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide corresponding to a region of Mouse

Target

Hand2 is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. It is required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. It plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Hand2 is involved in the development of branchial arches, which give rise to unique structures in the head and neck.

Partner Proteins

Nkx2-5; Hand1; Tcf3; Tcf4; Tcf12; Hoxd13; Twist1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 87%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

24kDa

Shipping Conditions

Wet Ice

Protein Length

217

NCBI Gene Symbol

HAND2

NCBI GB Accession Number

Hand2

Host or Source

Rabbit

Protein Name

Heart- and neural crest derivatives-expressed protein 2

Nucleotide Accession Number

NM_010402

Peptide Sequence

DQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQ

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