TERT Antibody - C-terminal region: Biotin (ARP30229_P050-Biotin)

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

TPP1; AKT1; HSP90AA1; HSPA4; DDX51; C19orf40; STEAP4; PBK; PHF20L1; TIMM21; PABPC1; SERBP1; SLC7A11; U2SURP; CCT5; ACAA2; TUBA1B; DYNLL1; UBE2D3; TGFBR2; PPIA; PFDN1; IREB2; GLA; ENO1; EIF2S1; ATP5B; ANXA2; CIB1; UBC; vpr; VPRBP; RUVBL2; RUVBL1; TERC; DKC

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.