HSP90AA1 Antibody - N-terminal region : Biotin (ARP30184_P050-Biotin)

Product Specifications

Gene Name

Heat shock protein 90kDa alpha (cytosolic), class A member 1

Gene Aliases

EL52, HSPN, LAP2, HSP86, HSPC1, HSPCA, Hsp89, Hsp90, LAP-2, HSP89A, HSP90A, HSP90N, Hsp103, HSPCAL1, HSPCAL4, HEL-S-65p

Gene ID

3320

Swiss Prot

P07900

Accession Number

NP_001017963

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human HSP90AA1

Target

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) .

Partner Proteins

AHSA1; STUB1; HUWE1; ISG15; RAF1; PTGDS; PTGDR; SIRT1; CDC37; STIP1; HSF1; HIF1A; NR3C1; UBC; PTGES3; FUS; CDC25C; CDK1; SUMO1; STK36; KEAP1; PSMD10; AURKA; SUMO2; SUMO3; MAP3K11; MDM2; LGALS3BP; CEP57; AURKB; CEP76; VHL; TUBG1; TP53; BRCA1; CEP250; AIP

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

HSP90AA1 is strongly supported by BioGPS gene expression data to be expressed in MCF7

Concentration

0.5 mg/ml

Homology

Cow: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.